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Article

Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients.

Pharmacogenomics - 1 Feb 2011

Lemos Clara, Giovannetti Elisa, Zucali Paolo A, Assaraf Yehuda G, Scheffer George L, van der Straaten Tahar, D'Incecco Armida, Falcone Alfredo, Guchelaar Henk-Jan, Danesi Romano, Santoro Armando, Giaccone Giuseppe, Tibaldi Carmelo, Peters Godefridus J

Abstract excerpt

AIMS: The current study investigates whether or not functional polymorphisms in the ATP-binding cassette transporter gene ABCG2 might affect gefitinib activity and/or toxicity in non-small-cell lung cancer (NSCLC) patients. MATERIALS & METHODS: Towards this end, ABCG2 polymorphisms and expression were assessed in DNA and tumors from 94 NSCLC patients treated with gefitinib, whereas their associations with...

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Identifiers

PMID: 21332310
DOI: 10.2217/pgs.10.172
PMCID: PMC7423195

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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