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Article

The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

Viral immunology - 1 Jun 2012

Chentoufi Aziz Alami, Dervillez Xavier, Dasgupta Gargi, Nguyen Chelsea, Kabbara Khaled W, Jiang Xianzhi, Nesburn Anthony B, Wechsler Steven L, Benmohamed Lbachir

Abstract excerpt

We recently found that the herpes simplex virus-1 (HSV-1) latency-associated transcript (LAT) results in exhaustion of virus-specific CD8⁺ T cells in latently-infected trigeminal ganglia (TG). In this study we sought to determine if this impairment may involve LAT directly and/or indirectly interfering with DC maturation. We found that a small number of HSV-1 antigen-positive DCs are present in the TG of...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpes Simplex

Share to Herpesvirus 1, Human

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Share to Trigeminal Ganglion

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Source

Open in PubMed Open full text

Identifiers

PMID: 22512280
DOI: 10.1089/vim.2011.0091
PMCID: PMC3366336

Genes

LAT
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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