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Intracellular Streptococcus pyogenes in Human Macrophages Display an Altered Gene Expression Profile

12 Apr 2012

Abstract excerpt

Streptococcus pyogenes is an important human pathogen, which has recently gained recognition as an intracellular microorganism during the course of severe invasive infections such as necrotizing fasciitis. Although the surface anchored M protein has been identified as a pivotal factor affecting phagosomal maturation and S. pyogenes survival within macrophages, the overall transcriptional profile required for the...

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PMID: 22511985
DOI: 10.1371/journal.pone.0035218

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