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Article

Transcriptome studies on Streptococcus pneumoniae, illustration of early response genes to THP-1 human macrophages.

Genomics - 1 Jan 2009

Song Xin-Ming, Connor Wayne, Hokamp Karsten, Babiuk Lorne A, Potter Andrew A

Abstract excerpt

Pathogen-host interaction plays an essential role in pathogenicity. In this study, we investigated transcriptomes of one Streptococcus pneumoniae TIGR4-derived unencapsulated strain upon exposure to THP-1 human macrophage-like cells for 0.5 h, 1 h and 3 h, respectively. Expression of most genes was up-regulated and the changes of selected genes were validated by qRT-PCR. To characterize the functions of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18848982
DOI: 10.1016/j.ygeno.2008.09.008

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