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Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis

16 Apr 2012

Abstract excerpt

A gene cluster encoding the biosynthesis of the fungal tropolone stipitatic acid was discovered in Talaromyces stipitatus (Penicillium stipitatum) and investigated by targeted gene knockout. A minimum of three genes are required to form the tropolone nucleus: tropA encodes a nonreducing polyketide synthase which releases 3-methylorcinaldehyde; tropB encodes a FAD-dependent monooxygenase which dearomatizes...

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PMID: 22508998
DOI: 10.1073/pnas.1201469109

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