Article
Investigation of two Wnt signalling pathway single nucleotide polymorphisms in a breast cancer-affected Australian population.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Dec 2011
Gabrovska Plamena N, Smith Robert A, Haupt Larisa M, Griffiths Lyn R
Abstract excerpt
In the mammary gland, Wnt signals are strongly implicated in initial development of the mammary rudiments and in the ductal branching and alveolar morphogenesis that occurs during pregnancy. Previously, we identified two Wnt signaling pathway-implicated genes, PPP3CA and MARK4, as having a role in more aggressive and potentially metastatic breast tumors. In this study, we examined two SNPs within PPP3CA and MARK4...
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