Article
A genetic variant located in miR-423 is associated with reduced breast cancer risk.
Cancer genomics & proteomics - 1 Jan 2000
Smith Robert A, Jedlinski Dominik J, Gabrovska Plamena N, Weinstein Stephen R, Haupt Larisa, Griffiths Lyn R
Abstract excerpt
BACKGROUND/AIM: Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A > C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development. MATERIALS AND METHODS: Caucasian Australian women...
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