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Investigation of the 1758G>C and 2880A>G variants within the NCOA3 gene in a breast cancer affected Australian population.

Gene - 15 Aug 2011

Gabrovska P N, Smith R A, O'Leary G, Haupt L M, Griffiths L R

Abstract excerpt

NCOA3 is a known low to moderate-risk breast cancer susceptibility gene, amplified in 5-10% and over expressed in about 60% of breast tumours. Additionally, this over expression is associated with Tamoxifen resistance and poor prognosis. Previously, two variants of NCOA3, 1758G>C and 2880A>G have been associated with breast cancer in two independent populations. Here we assessed the influence of the two NCOA3...

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Identifiers

PMID: 21601620
DOI: 10.1016/j.gene.2011.05.001

Genes

NCOA3

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