B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease.

doi:10.1371/journal.pone.0033891

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Article

B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease.

PloS one - 1 Jan 2012

Satoh Takeshi, Smith Alexander, Sarde Aurelien, Lu Hui-chun, Mian Syed, Mian Sophie, Trouillet Celine, Mufti Ghulam, Emile Jean-Francois, Fraternali Franca, Donadieu Jean, Geissmann Frederic

Abstract excerpt

BACKGROUND: Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or 'LCH cells'. Badalian-Very et al. recently reported the presence of a canonical (V600E)B-RAF mutation in 57% of paraffin-embedded biopsies from LCH granuloma....

Topics

Alleles
Amino Acid Sequence
Child
Child, Preschool
Extracellular Signal-Regulated MAP Kinases
Female
Genetic Predisposition to Disease
Granuloma
HEK293 Cells
Histiocytosis, Langerhans-Cell
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Lymphocytes

Male

Molecular Sequence Data

Monocytes

Mutation

Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 22506009
DOI: 10.1371/journal.pone.0033891
PMCID: PMC3323620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22506009-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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