Article
B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease.
PloS one - 1 Jan 2012
Satoh Takeshi, Smith Alexander, Sarde Aurelien, Lu Hui-chun, Mian Syed, Mian Sophie, Trouillet Celine, Mufti Ghulam, Emile Jean-Francois, Fraternali Franca, Donadieu Jean, Geissmann Frederic
Abstract excerpt
BACKGROUND: Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or 'LCH cells'. Badalian-Very et al. recently reported the presence of a canonical (V600E)B-RAF mutation in 57% of paraffin-embedded biopsies from LCH granuloma. Here we confirm their findings and report the identification of two novel B-RAF mutations detected in LCH patients....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.