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Article

Measurement of multiple drug resistance transporter activity in putative cancer stem/progenitor cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Donnenberg Vera S, Meyer E Michael, Donnenberg Albert D

Abstract excerpt

Multiple drug resistance, mediated by the expression and activity of ABC-transporters, is a major obstacle to antineoplastic therapy. Normal tissue stem cells and their malignant counterparts share MDR transporter activity as a major mechanism of self-protection. Although MDR activity is upregulated in response to substrate chemotherapeutic agents, it is also constitutively expressed on both normal tissue stem...

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Identifiers

PMID: 19582433
DOI: 10.1007/978-1-59745-280-9_17
PMCID: PMC4165075

Genes

ABCB1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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