Article
MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance.
Animal genetics - 1 Dec 2012
McGivney Beatrice A, Browne John A, Fonseca Rita G, Katz Lisa M, Machugh David E, Whiston Ronan, Hill Emmeline W
Abstract excerpt
Myostatin, encoded by the MSTN gene, is a member of the TGF-β superfamily that regulates skeletal muscle development. A MSTN SNP significantly associated with Thoroughbred horse racing phenotypes has recently been identified as well as significant reductions in Thoroughbred skeletal muscle gene expression for three transcripts 400-1500 base pairs downstream of the MSTN gene following a period of training....
Topics
- Animals
- Female
- Gene Expression
- Gene Expression Regulation
- Genotype
- Horses
- Male
- Motor Activity
- Muscle, Skeletal
- Myostatin
- Physical Conditioning, Animal