Article
SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression.
Molecular cancer research : MCR - 1 Jun 2012
Matsushita Kazuyuki, Kajiwara Toshiko, Tamura Mai, Satoh Mamoru, Tanaka Nobuko, Tomonaga Takeshi, Matsubara Hisahiro, Shimada Hideaki, Yoshimoto Rei, Ito Akihiro, Kubo Shuji, Natsume Tohru, Levens David, Yoshida Minoru, Nomura Fumio
Abstract excerpt
The Far UpStream Element (FUSE)-binding protein-interacting repressor (FIR), a c-myc transcriptional suppressor, is alternatively spliced removing the transcriptional repression domain within exon 2 (FIRΔexon2) in colorectal cancers. SAP155 is a subunit of the essential splicing factor 3b (SF3b)...
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