Article
Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.
The Journal of investigative dermatology - 1 Aug 2012
Jones Christine L, Ferreira Silvia, McKenzie Robert C T, Tosi Isabella, Caesar Jacqueline A, Bagot Martine, Whittaker Sean J, Mitchell Tracey J
Abstract excerpt
T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent in cells of hematopoietic origin. Aberrant PLS3 expression has been demonstrated in lymphocytes from Sézary syndrome (SS) patients and has been proposed as a biomarker for SS; however, the mechanism underlying dysregulation of PLS3 has not been determined. In this study, PLS3 mRNA expression was demonstrated in 21/35...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.