Article
Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans.
BMC medical genetics - 11 Apr 2012
Kidambi Srividya, Ghosh Soumitra, Kotchen Jane M, Grim Clarence E, Krishnaswami Shanthi, Kaldunski Mary L, Cowley Allen W, Patel Shailendra B, Kotchen Theodore A
Abstract excerpt
BACKGROUND: A recent genome wide association study in 1017 African Americans identified several single nucleotide polymorphisms that reached genome-wide significance for systolic blood pressure. We attempted to replicate these findings in an independent sample of 2474 unrelated African Americans in the Milwaukee metropolitan area; 53% were women and 47% were hypertensives. METHODS: We evaluated sixteen top...
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