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Article

Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium channel of Anopheles gambiae.

Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2012

Jones Christopher M, Liyanapathirana Milindu, Agossa Fiacre R, Weetman David, Ranson Hilary, Donnelly Martin James, Wilding Craig S

Abstract excerpt

Insecticide resistance is an ideal model to study the emergence and spread of adaptative variants. In the African malaria mosquito, Anopheles gambiae, this is complemented by a strong public health rationale. In this insect, resistance to pyrethroid and DDT insecticides is strongly associated with the mutations L1014F and L1014S within the para voltage-gated sodium channel (VGSC). Across much of West Africa,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22493253
DOI: 10.1073/pnas.1201475109
PMCID: PMC3340067

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DDT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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