Article
Multiple origins of knockdown resistance mutations in the Afrotropical mosquito vector Anopheles gambiae.
PloS one - 28 Nov 2007
Pinto João, Lynd Amy, Vicente José L, Santolamazza Federica, Randle Nadine P, Gentile Gabriele, Moreno Marta, Simard Frédéric, Charlwood Jacques Derek, do Rosário Virgílio E, Caccone Adalgisa, Della Torre Alessandra, Donnelly Martin J
Abstract excerpt
How often insecticide resistance mutations arise in natural insect populations is a fundamental question for understanding the evolution of resistance and also for modeling its spread. Moreover, the development of resistance is regarded as a favored model to study the molecular evolution of adaptive traits. In the malaria vector Anopheles gambiae two point mutations (L1014F and L1014S) in the voltage-gated sodium...
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