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Article

Reduced calreticulin levels link endoplasmic reticulum stress and Fas-triggered cell death in motoneurons vulnerable to ALS.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Apr 2012

Bernard-Marissal Nathalie, Moumen Anice, Sunyach Claire, Pellegrino Christophe, Dudley Keith, Henderson Christopher E, Raoul Cédric, Pettmann Brigitte

Abstract excerpt

Cellular responses to protein misfolding are thought to play key roles in triggering neurodegeneration. In the mutant superoxide dismutase (mSOD1) model of amyotrophic lateral sclerosis (ALS), subsets of motoneurons are selectively vulnerable to degeneration. Fast fatigable motoneurons selectivel...

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Source

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Identifiers

PMID: 22492046
DOI: 10.1523/JNEUROSCI.5431-11.2012
PMCID: PMC6620921

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22492046-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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