Article
Dihydropyrimidine dehydrogenases and cytidine-deaminase gene polymorphisms as outcome predictors in resected gastric cancer patients treated with fluoropyrimidine adjuvant chemotherapy.
Journal of surgical oncology - 1 Aug 2008
Grau Juan J, Caballero Miguel, Monzó Mariano, Muñoz-García Carmen, Domingo-Domenech Jose, Navarro Alfons, Conill Carlos, Campayo Marc, Bombí Jose A
Abstract excerpt
BACKGROUND AND OBJECTIVES: Single nucleotide polymorphisms of dihydropyrimidine dehydrogenases gene (DPYD) induces dihydropyrimidine dehydrogenase enzyme (DPD) deficiency resulting in increased activity of 5-fluorouracil derivatives. Cytidine-deaminase gene (CDA) polymorphisms have been involved...
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