Article
Organization, structure, and polymorphisms of the human profilaggrin gene.
Biochemistry - 9 Oct 1990
Gan S Q, McBride O W, Idler W W, Markova N, Steinert P M
Abstract excerpt
Profilaggrin is a major protein component of the keratohyalin granules of mammalian epidermis. It is initially expressed as a large polyprotein precursor and is subsequently proteolytically processed into individual functional filaggrin molecules. We have isolated genomic DNA and cDNA clones encoding the 5'- and 3'-ends of the human gene and mRNA. The data reveal the presence of likely "CAT" and "TATA" sequences,...
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