Article
Organization, structure, and polymorphisms of the human profilaggrin gene.
Biochemistry - 9 Oct 1990
Gan S Q, McBride O W, Idler W W, Markova N, Steinert P M
Abstract excerpt
Profilaggrin is a major protein component of the keratohyalin granules of mammalian epidermis. It is initially expressed as a large polyprotein precursor and is subsequently proteolytically processed into individual functional filaggrin molecules. We have isolated genomic DNA and cDNA clones enco...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA
- Female
- Filaggrin Proteins
- Humans
- Intermediate Filament Proteins
- Male
- Molecular Sequence Data
- Pedigree
- Polymorphism, Genetic
- Protein Precursors