Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance

doi:10.1021/acs.jnatprod.0c00334

Article

Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance

13 Aug 2020

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The expression of multidrug resistance P-glycoprotein (P-gp) by cancer cells represents one of the major drawbacks to successful cancer therapy. Accordingly, the development of drugs that inhibit the activity of this transporter remains a major challenge in cancer drug discovery. In this context, several new ecdysteroid derivatives have been synthesized and...

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