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Article

Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms.

Journal of affective disorders - 1 Nov 2012

Goenjian Armen K, Bailey Julia N, Walling David P, Steinberg Alan M, Schmidt Devon, Dandekar Uma, Noble Ernest P

Abstract excerpt

OBJECTIVE: To examine the potential contribution of the serotonin hydroxylase (TPH1 and TPH2) genes, and the serotonin transporter promoter polymorphism (5HTTLPR) to the unique and pleiotropic risk of PTSD symptoms and depressive symptoms. METHODS: Participants included 200 adults exposed to the 1988 Spitak earthquake from 12 multigenerational families (3 to 5 generations). Severity of trauma exposure, PTSD, and...

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Source

Identifiers

PMID: 22483952
DOI: 10.1016/j.jad.2012.02.015

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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