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Article

Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake.

Cell metabolism - 4 Apr 2012

Zeve Daniel, Seo Jin, Suh Jae Myoung, Stenesen Drew, Tang Wei, Berglund Eric D, Wan Yihong, Williams Linda J, Lim Ajin, Martinez Myrna J, McKay Renée M, Millay Douglas P, Olson Eric N, Graff Jonathan M

Abstract excerpt

Adipose tissues provide circulating nutrients and hormones. We present in vivo mouse studies highlighting roles for Wnt signals in both aspects of metabolism. β-catenin activation in PPARγ-expressing fat progenitors (PBCA) decreased fat mass and induced fibrotic replacement of subcutaneous fat specifically. In spite of lipodystrophy, PBCA mice did not develop the expected diabetes and hepatosteatosis, but rather...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22482731
DOI: 10.1016/j.cmet.2012.03.010
PMCID: PMC3325026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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