Article
Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling.
PloS one - 1 Jan 2012
Fesel Constantin, Barreto Marta, Ferreira Ricardo C, Costa Nuno, Venda Lara L, Pereira Clara, Carvalho Claudia, Morães-Fontes Maria Francisca, Ferreira Carlos M, Vasconcelos Carlos, Viana João F, Santos Eugenia, Martins Berta, Demengeot Jocelyne, Vicente Astrid M
Abstract excerpt
In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity, usually without ever acquiring the disease. We studied relations of IgG autoantibody profiles and peripheral blood activated regulatory T-cells (aTregs), represented...
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