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Article

Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes.

Archives of general psychiatry - 1 Apr 2012

Schellekens Arnt F A, Franke Barbara, Ellenbroek Bart, Cools Alexander, de Jong Cor A J, Buitelaar Jan K, Verkes Robbert-Jan

Abstract excerpt

CONTEXT: Alcohol dependence is a common neuropsychiatric disorder with high heritability. However, genetic association studies on alcohol dependence are often troubled by nonreplication. The use of intermediate phenotypes may help make clear the mode of action of various candidate genes and improve the reproducibility of genetic association studies. OBJECTIVE: To test central dopamine receptor sensitivity as an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to Receptors, Dopamine D2

Source

Identifiers

PMID: 22474103
DOI: 10.1001/archgenpsychiatry.2011.1335

Genes

COMT
DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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