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Article

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

30 Mar 2012

Abstract excerpt

Human epidermal growth factor receptor 2 (HER2) expression in breast cancer is associated with an aggressive phenotype and poor prognosis, making it an appealing therapeutic target. Trastuzumab, an HER2 antibody-based inhibitor, is currently the leading targeted treatment for HER2(+)-breast cancers. Unfortunately, many patients inevitably develop resistance to the therapy, highlighting the need for alternative...

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Share to Advanced biosensing and bioanalysis techniques
Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 22467215
DOI: 10.1093/nar/gks294

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