Article
Interleukin-2 bolus therapy induces immediate and selective disappearance from peripheral blood of all lymphocyte subpopulations displaying natural killer activity: role of cell adhesion to endothelium.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1992
Salvo G, Samoggia P, Masciulli R, Boccoli G, Allavena P, Mariani G, Bullo A, Montesoro E, Bulgarini D, Carlini P
Abstract excerpt
As early as 10-15 min after the start of a 30 min interleukin-2 (IL-2) infusion, a rapid, virtually complete disappearance of all natural killer (NK) lymphocyte subpopulations (including both CD3- CD56+ and CD3+ CD56+ cells with either alpha/beta or gamma/delta T-cell receptor) was observed from peripheral blood. In contrast, the number of T lymphocytes (CD3+ CD56-) was unmodified for at least 2 h after IL-2...
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