Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance.

BMC medical genetics - 30 Mar 2012

Jiang Shan, Fang Qichen, Yu Weihui, Zhang Rong, Hu Cheng, Dong Kun, Bao Yuqian, Wang Chen, Xiang Kunsan, Jia Weiping

Abstract excerpt

BACKGROUND: APPL1 and APPL2 are two adaptor proteins, which can mediate adiponectin signaling via binding to N terminus of adiponectin receptors in muscle cells. Genes encoding adiponectin and adiponectin receptors contribute to insulin resistance and the risk of obesity, and genetic variants of APPL1 are associated with body fat distribution. However, the association between genetic variations of APPL2 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Glucose Tolerance Test

Share to Linkage Disequilibrium

Share to Obesity

Share to Overweight

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 22462604
DOI: 10.1186/1471-2350-13-22
PMCID: PMC3368742

Genes

APPL2
APPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance.PMID 22462604Read ↗

[Association of variants in APPL1 gene with body fat and its distribution in Chinese patients with type 2 diabetic mellitus].Semantic proximity Read ↗

Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus.Semantic proximity Read ↗

Genetic variability in adapter proteins with APPL1/2 is associated with the risk of coronary artery disease in type 2 diabetes mellitus in Chinese Han population.Semantic proximity Read ↗

Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease.Semantic proximity Read ↗

Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China.Semantic proximity Read ↗

Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans.Semantic proximity Read ↗

Coding Variants are Relevant to the Expression of Obesity-Related Genes for Pediatric Adiposity.Semantic proximity Read ↗

A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population.Semantic proximity Read ↗

Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population.Semantic proximity Read ↗

Apelin gene polymorphism influences apelin expression and obesity phenotypes in Chinese women.Semantic proximity Read ↗

Association of adiponectin gene (ADIPOQ) rs2241766 polymorphism with obesity in adults: a meta-analysis.Semantic proximity Read ↗

Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.