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Article

Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease.

PloS one - 1 Jan 2013

Barbieri Michelangela, Esposito Antonietta, Angellotti Edith, Rizzo Maria Rosaria, Marfella Raffaele, Paolisso Giuseppe

Abstract excerpt

The importance of genetics and epigenetic changes in the pathogenesis of non alcoholic fatty liver disease (NAFLD) has been increasingly recognized. Adiponectin has a central role in regulating glucose and lipid metabolism and controlling inflammation in insulin-sensitive tissues and low adiponectin levels have been linked to NAFLD. APPL1 and APPL2 are adaptor proteins that interact with the intracellular region...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alanine Transaminase

Share to Fatty Liver

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Source

Open in PubMed Open full text

Identifiers

PMID: 23977033
DOI: 10.1371/journal.pone.0071391
PMCID: PMC3747137

Genes

APPL1
APPL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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