Article
Chemical genetic induction of meiosis in Schizosaccharomyces pombe.
Cell cycle (Georgetown, Tex.) - 15 Apr 2012
Guerra-Moreno Angel, Alves-Rodrigues Isabel, Hidalgo Elena, Ayté José
Abstract excerpt
In the fission yeast Schizosaccharomyces pombe, meiosis is inhibited by the protein kinase Pat1, which phosphorylates and inactivates Mei2, an RNA binding protein essential for the initiation of meiosis. When diploid cells are deprived of nutrients, they initiate a cascade of events leading to the inactivation of Pat1 and entry into meiosis. Strains carrying the temperature-sensitive pat1-114 allele are forced to...
Topics
- Adenosine Triphosphate
- Meiosis
- Mutation
- Protein Serine-Threonine Kinases
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Temperature