Article
Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe.
Cell cycle (Georgetown, Tex.) - 15 Sept 2010
Okuzaki Daisuke, Kasama Takashi, Hirata Aiko, Ohtaka Ayami, Kakegawa Reiko, Nojima Hiroshi
Abstract excerpt
Protein phosphorylation is pivotal for meiotic progression, but little is known about its regulatory mechanisms. We show that before meiosis I, the meiosis-specific Schizosaccharomyces pombe protein Spo5 is phosphorylated in vivo on T29, T55, S59 and/or T63. In a mutant strain expressing Spo5 fused to green fluorescent protein with alanine substitutions of these amino acid sites (GFP; Spo5-4A-GFP), the timely...
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