Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The DSPII splice variant is critical for desmosome-mediated HaCaT keratinocyte adhesion

1 Jan 2012

Abstract excerpt

Desmosomes are intercellular junctions specialised for strong adhesion that are prominent in the epidermis and heart muscle. Defective desmosomal function due to inherited mutations in the constitutive desmosomal gene desmoplakin (DSP) causes skin or heart disorders and in some instances both. Different mutations have different disease-causing molecular mechanisms as evidenced by the varying phenotypes resulting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Effects of Exercise
Share to Genetic Neurodegenerative Diseases
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22454510
DOI: 10.1242/jcs.084152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DSPII splice variant is critical for desmosome-mediated HaCaT keratinocyte adhesionPMID 22454510Read ↗

Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndromeSemantic proximity Read ↗

Epidermal growth factor receptor inhibition leads to cellular phenotype correction of DSP-mutated keratinocytes.Semantic proximity Read ↗

Desmosomal protein structure and function and the impact of disease-causing mutations.Semantic proximity Read ↗

PP2A-B55α controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminusSemantic proximity Read ↗

Mutations in genes encoding desmosomal proteins: spectrum of cutaneous and extracutaneous abnormalities.Semantic proximity Read ↗

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma.Semantic proximity Read ↗

Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament networkSemantic proximity Read ↗

Desmoplakin Haploinsu/iciency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional ActivationSemantic proximity Read ↗

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma.Semantic proximity Read ↗

Loss-of-Function Mutations in SERPINB8 Linked to Exfoliative Ichthyosis with Impaired Mechanical Stability of Intercellular Adhesions.Semantic proximity Read ↗

Loss‐of‐function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotypeSemantic proximity Read ↗

The Desmosomal Plaque Proteins of the Plakophilin FamilySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.