Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dichotomous effects of VEGF-A on adipose tissue dysfunction.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

Sun Kai, Wernstedt Asterholm Ingrid, Kusminski Christine M, Bueno Ana Carolina, Wang Zhao V, Pollard Jeffrey W, Brekken Rolf A, Scherer Philipp E

Abstract excerpt

Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, and ultimately insulin resistance. We hypothesized that VEGF-A-induced stimulation of angiogenesis enables sustained and sufficient oxygen and nutrient exchange during fat mass expansion, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipose Tissue, White
Share to Angiogenesis Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Hypoxia

Share to Dietary Fats

Share to Mice, Obese

Share to Neovascularization, Physiologic

Share to Vascular Endothelial Growth Factor Receptor-2

Source

Open in PubMed Open full text

Identifiers

PMID: 22451920
DOI: 10.1073/pnas.1200447109
PMCID: PMC3326476

Genes

UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22451920-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dichotomous effects of VEGF-A on adipose tissue dysfunction.PMID 22451920Read ↗

Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation.Semantic proximity Read ↗

Role of VEGFs in metabolic disorders.Semantic proximity Read ↗

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.Semantic proximity Read ↗

VEGF and VEGFB Play Balancing Roles in Adipose Differentiation, Gene Expression, and FunctionSemantic proximity Read ↗

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagySemantic proximity Read ↗

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue.Semantic proximity Read ↗

Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in miceSemantic proximity Read ↗

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagySemantic proximity Read ↗

Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese miceSemantic proximity Read ↗

Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction.Semantic proximity Read ↗

Adipose tissue, angiogenesis and angio-MIR under physiological and pathological conditionsSemantic proximity Read ↗

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.