Article
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2008
Xue Yuan, Cao Renhai, Nilsson Daniel, Chen Shaohua, Westergren Rickard, Hedlund Eva-Maria, Martijn Cecile, Rondahl Lena, Krauli Per, Walum Erik, Enerbäck Sven, Cao Yihai
Abstract excerpt
Adipogenesis is spatiotemporally coupled to angiogenesis throughout adult life, and the interplay between these two processes is communicated by multiple factors. Here we show that in a transgenic mouse model, increased expression of forkhead box C2 (FOXC2) in the adipose tissue affects angiogenesis, vascular patterning, and functions. White and brown adipose tissues contain a considerably high density of...
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