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Article

Epigenetic Dysregulation of Virulence Gene Expression in Severe Plasmodium falciparum Malaria

23 Mar 2012

Abstract excerpt

Chronic infections with the human malaria parasite Plasmodium falciparum depend on antigenic variation. P. falciparum erythrocyte membrane protein 1 (PfEMP1), the major erythrocyte surface antigen mediating parasite sequestration in the microvasculature, is encoded in parasites by a highly diverse family of var genes. Antigenic switching is mediated by clonal variation in var expression, and recent in vitro...

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PMID: 22448008
DOI: 10.1093/infdis/jis239

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