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Article

Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells

23 Mar 2012

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22447124
DOI: 10.1007/s00204-012-0810-x

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Related research

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Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cellsPMID 22447124Read ↗

Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cellsSemantic proximity Read ↗

Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.Semantic proximity Read ↗

The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytesSemantic proximity Read ↗

EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells.Semantic proximity Read ↗

Impaired autophagic flux and p62-mediated EMT are involved in arsenite-induced transformation of L-02 cellsSemantic proximity Read ↗

The Repressive Effect of NF-κB on p53 by Mot-2 Is Involved in Human Keratinocyte Transformation Induced by Low Levels of ArseniteSemantic proximity Read ↗

Angiogenesis, mediated by miR-21, is involved arsenite-induced carcinogenesisSemantic proximity Read ↗

MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells.Semantic proximity Read ↗

HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugsSemantic proximity Read ↗

Poly(ADP-Ribose) Polymerase-1 Inhibition by Arsenite Promotes the Survival of Cells With Unrepaired DNA Lesions Induced by UV ExposureSemantic proximity Read ↗

Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway.Semantic proximity Read ↗

ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.Semantic proximity Read ↗

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