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Article

Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes.

Clinical endocrinology - 1 Sept 2012

Kim Jin Ju, Choi Young Min, Cho Young Min, Hong Min A, Chae Soo Jin, Hwang Kyu Ri, Hwang Seung Sik, Yoon Sang Ho, Moon Shin Yong

Abstract excerpt

OBJECTIVE: Insulin resistance is a core feature of polycystic ovary syndrome (PCOS). Recently, genome-wide association studies have reported a number of single-nucleotide polymorphisms (SNPs) with reproducible associations and susceptibilities to type 2 diabetes. We examined the potential association between the diabetogenic genes uncovered in the genome-wide association studies and PCOS in Korean women. DESIGN:...

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Source

Identifiers

PMID: 22443257
DOI: 10.1111/j.1365-2265.2012.04389.x

Genes

CDKAL1
FTO
HHEX
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes.PMID 22443257Read ↗

Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2 are not associated with polycystic ovary syndrome in Chinese women.Semantic proximity Read ↗

rs7903146 mutation of Type 2 diabetes mellitus-related gene TCF7L2 is not associated with polycystic ovary syndrome in a cohort of Turkey.Semantic proximity Read ↗

Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes.Semantic proximity Read ↗

Common variants of transcription factor 7-like 2 (TCF7L2) are associated with reduced insulin secretion in women with polycystic ovary syndrome.Semantic proximity Read ↗

Associations of single nucleotide polymorphisms related to insulin resistance with polycystic ovary syndrome.Semantic proximity Read ↗

Transcription Factor-7-Like 2 Gene Variants Affect the Metabolic Phenotypes of Polycystic Ovary Syndrome.Semantic proximity Read ↗

Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS.Semantic proximity Read ↗

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.Semantic proximity Read ↗

Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systemic review and meta-analysis.Semantic proximity Read ↗

Polymorphisms of TCF7L2 gene in South Brazilian women with polycystic ovary syndrome: a cross-sectional study.Semantic proximity Read ↗

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.Semantic proximity Read ↗

Association of type 2 diabetes mellitus genes in polycystic ovary syndrome aetiology among women from southern India.Semantic proximity Read ↗

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