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Article

Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systemic review and meta-analysis.

Journal of ovarian research - 6 Jan 2025

Shah Idrees A, Rashid Rabiya, Rashid Haroon, Bhat Abid, Ganie Mohd Ashraf

Abstract excerpt

BACKGROUND: A significant overlap in the pathophysiological features of polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) has been reported; and insulin resistance is considered a central driver in both. The expression and hepatic clearance of insulin and subsequent glucose homeostasis are mediated by TCF7L2 via Wnt signaling. Studies have persistently associated TCF7L2 genetic variations with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39762965
DOI: 10.1186/s13048-024-01585-z
PMCID: PMC11702189

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Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systemic review and meta-analysis.PMID 39762965Read ↗

Relationships between TCF7L2 genetic polymorphisms and polycystic ovary syndrome risk: a meta-analysis.Semantic proximity Read ↗

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