Preeclampsia Up-Regulates Angiogenesis-Associated MicroRNA ( <i>i.e</i> ., miR-17, -20a, and -20b) That Target Ephrin-B2 and EPHB4 in Human Placenta

Abstract excerpt

CONTEXT: Placental angiogenesis contributes to the pathogenesis of preeclampsia (PE) that affects 5-8% of all human pregnancies. MicroRNA (miRNA) are a class of noncoding 21- to 25-nucleotide RNA that negatively regulate gene expression posttranscriptionly. OBJECTIVE: The aim of this study was to test the hypothesis that miRNA are differentially expressed in healthy term and PE placentas and a subclass of...

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