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Article

Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration

11 Oct 2018

Abstract excerpt

Preeclampsia (PE) is a common cause of maternal morbidity, characterized by impaired trophoblast invasion and spiral artery transformation resulting in progressive uteroplacental hypoxia. Given the primary role of LIN28A and LIN28B in modulating cell metabolism, differentiation, and invasion, we hypothesized that LIN28A and/or LIN28B regulates trophoblast differentiation and invasion, and that its dysregulation...

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PMID: 30307771
DOI: 10.1096/fj.201801163r

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