Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transforming the Untransformable: Application of Direct Transformation To Manipulate Genetically Staphylococcus aureus and Staphylococcus epidermidis

22 Mar 2012

Abstract excerpt

UNLABELLED: The strong restriction barrier present in Staphylococcus aureus and Staphylococcus epidermidis has limited functional genomic analysis to a small subset of strains that are amenable to genetic manipulation. Recently, a conserved type IV restriction system termed SauUSI (which specifically recognizes cytosine methylated DNA) was identified as the major barrier to transformation with foreign DNA. Here...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Resistance in Staphylococcus
Share to Bacterial Genetics and Biotechnology
Share to Clostridium difficile and Clostridium perfringens research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22434850
DOI: 10.1128/mbio.00277-11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transforming the Untransformable: Application of Direct Transformation To Manipulate Genetically Staphylococcus aureus and Staphylococcus epidermidisPMID 22434850Read ↗

Functional genomics reveals extensive diversity in <i>Staphylococcus epidermidis</i> restriction modification systems compared to <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Bypassing the Restriction System To Improve Transformation of Staphylococcus epidermidisSemantic proximity Read ↗

Complete Bypass of Restriction Systems for Major Staphylococcus aureus Lineages.Semantic proximity Read ↗

Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction ModificationSemantic proximity Read ↗

A type III-like restriction endonuclease functions as a major barrier to horizontal gene transfer in clinical <i>Staphylococcus aureus</i> strainsSemantic proximity Read ↗

Inactivation of the SauI Type I Restriction-Modification System Is Not Sufficient To Generate Staphylococcus aureus Strains Capable of Efficiently Accepting Foreign DNASemantic proximity Read ↗

Genetic engineering of <i>Staphylococcus haemolyticus</i> : Overcoming Restriction-Modification Barriers and Targeting Virulence GenesSemantic proximity Read ↗

Efficient Genome Editing in Most Staphylococcus aureus by Using the Restriction-Modification System Silent CRISPR-Cas9 ToolkitSemantic proximity Read ↗

Sau1: a novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages.Semantic proximity Read ↗

An update on the molecular genetics toolbox for staphylococciSemantic proximity Read ↗

Efficient and Scalable Precision Genome Editing in Staphylococcus aureus through Conditional Recombineering and CRISPR/Cas9-Mediated CounterselectionSemantic proximity Read ↗

Impact of target site distribution for Type I restriction enzymes on the evolution of methicillin-resistant Staphylococcus aureus (MRSA) populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.