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Article

Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B.

Chembiochem : a European journal of chemical biology - 23 Nov 2007

Bode Helge B, Meiser Peter, Klefisch Thorsten, Cortina Niña Socorro d j, Krug Daniel, Göhring Anke, Schwär Gertrud, Mahmud Taifo, Elnakady Yasser A, Müller Rolf

Abstract excerpt

Myxalamids are potent inhibitors of the eukaryotic electron transport chain produced by different myxobacteria. Here, we describe the identification of the myxalamid biosynthesis gene cluster from Myxococcus xanthus. Additionally, new myxalamids (5-13) have been obtained by mutasynthesis from bkd mutants of M. xanthus and Stigmatella aurantiaca. Moreover, as these bkd mutants are still able to produce myxalamid B...

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PMID: 17955482
DOI: 10.1002/cbic.200700401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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