Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells

4 Jan 2012

Abstract excerpt

It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA damage and repair gene expression (mRNA) are not clarified yet. We investigated the effects of deguelin on DNA damage and associated gene expression in human lung cancer NCI-H460...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22227970
DOI: 10.3892/or.2012.1622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cellsPMID 22227970Read ↗

Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells.Semantic proximity Read ↗

Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-κB Signaling PathwaysSemantic proximity Read ↗

Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitroSemantic proximity Read ↗

DNA damage caused by chemotherapy has duality, and traditional Chinese medicine may be a better choice to reduce its toxicitySemantic proximity Read ↗

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer CellsSemantic proximity Read ↗

Laboratory and clinical studies of cancer chemoprevention by antioxidants in berriesSemantic proximity Read ↗

Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cellsSemantic proximity Read ↗

DNA damage protection: an excellent application of bioactive compoundsSemantic proximity Read ↗

Unveiling the Potential of Watermelon Rind Extract: Impact on Cell Proliferation, Apoptosis, Senescence, and Transcriptomic Profile in Human Renal Adenocarcinoma CellsSemantic proximity Read ↗

Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLaSemantic proximity Read ↗

Lutein inhibits tumor progression through the ATR /Chk1/p53 signaling pathway in non‐small cell lung cancerSemantic proximity Read ↗

Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.