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Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development

20 Aug 2024

Abstract excerpt

OBJECTIVES: T helper 9 (Th9) cells are recognised for their characteristic expression of the transcription factor PU.1 and production of interleukin-9 (IL-9), which has been implicated in various autoimmune diseases. However, its precise relationship with rheumatoid arthritis (RA) pathogenesis needs to be further clarified. METHODS: The expression levels of PU.1 and IL-9 in patients with RA were determined by...

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PMID: 39164066
DOI: 10.1136/ard-2024-226067

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