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Article

Trps1 is necessary for normal temporomandibular joint development.

Cell and tissue research - 1 Apr 2012

Michikami Ikumi, Fukushi Toshiya, Honma Shiho, Yoshioka Seisuke, Itoh Shunji, Muragaki Yasuteru, Kurisu Kojiro, Ooshima Takashi, Wakisaka Satoshi, Abe Makoto

Abstract excerpt

Mutation of the human TRPS1 gene leads to trichorhinophalangeal syndrome (TRPS), which is characterized by an abnormal development of various organs including the craniofacial skeleton. Trps1 has recently been shown to be expressed in the jaw joints of zebrafish; however, whether Trps1 is expressed in the mammalian temporomandibular joint (TMJ), or whether it is necessary for TMJ development is unknown. We have...

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Source

Identifiers

PMID: 22427063
DOI: 10.1007/s00441-012-1372-1

Genes

TRPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Trps1 is necessary for normal temporomandibular joint development.PMID 22427063Read ↗

Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice.Semantic proximity Read ↗

Trps1 Regulates Development of Craniofacial Skeleton and Is Required for the Initiation of Palatal Shelves FusionSemantic proximity Read ↗

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Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesisSemantic proximity Read ↗

Tricho-Rhino-Phalangeal Syndrome with Supernumerary TeethSemantic proximity Read ↗

The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles.Semantic proximity Read ↗

Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes.Semantic proximity Read ↗

Identification of the GATA Factor TRPS1 as a Repressor of the Osteocalcin PromoterSemantic proximity Read ↗

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.Semantic proximity Read ↗

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