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Article

Replication of murine coronavirus requires multiple cysteines in the endodomain of spike protein.

Virology - 5 Jun 2012

Yang Jinhua, Lv Jun, Wang Yuyan, Gao Shuang, Yao Qianqian, Qu Di, Ye Rong

Abstract excerpt

A conserved cysteine-rich motif located between the transmembrane domain and the endodomain is essential for membrane fusion and assembly of coronavirus spike (S) protein. Here, we proved that three cysteines within the motif, but not dependent on position, are minimally required for the survival of the recombinant mouse hepatitis virus. When the carboxy termini with these mutated motifs of S proteins were...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytopathogenic Effect, Viral

Share to Gene Expression Regulation, Viral

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Source

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Identifiers

PMID: 22424735
DOI: 10.1016/j.virol.2012.02.015
PMCID: PMC7111998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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