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Article

Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.

BMC medical genetics - 17 Mar 2012

Potts Lisa F, Cambon Alex C, Ross Owen A, Rademakers Rosa, Dickson Dennis W, Uitti Ryan J, Wszolek Zbigniew K, Rai Shesh N, Farrer Matthew J, Hein David W, Litvan Irene

Abstract excerpt

BACKGROUND: There are no known causes for progressive supranuclear palsy (PSP). The microtubule associated protein tau (MAPT) H1 haplotype is the major genetic factor associated with risk of PSP, with both oxidative stress and mitochondrial dysfunction also implicated. We investigated whether specific single nucleotide polymorphisms (SNPs) in genes encoding enzymes of xenobiotic detoxification, mitochondrial...

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Share to Arylamine N-Acetyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

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Source

Open in PubMed Open full text

Identifiers

PMID: 22424094
DOI: 10.1186/1471-2350-13-16
PMCID: PMC3344705

Genes

NAT2
MAPT
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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