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Article

A single nucleotide polymorphism that affects oligodendroglial lineage cells may augment the consequences of neurotoxicants.

Neurotoxicology - 1 May 2026

Poretz Ronald D

Abstract excerpt

An increasing number of toxicants are found to target oligodendroglia lineage cells. Among them, environmental lead and oral alcohol reduce oligodendrogenesis and affect oligodendrocyte precursor cells (OPCs). OPCs perform a multitude of functions within the neuronal synaptic space and serve as progenitors to myelin capable oligodendrocytes. Aberrant OPCs result in neurobehavioral deficits in humans. A single...

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Identifiers

PMID: 42002102
DOI: 10.1016/j.neuro.2026.103457

Genes

ARSA

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