Article
K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
Molecular oncology - 1 Sept 2017
Yeung Yvonne, Lau David K, Chionh Fiona, Tran Hoanh, Tse Janson W T, Weickhardt Andrew J, Nikfarjam Mehrdad, Scott Andrew M, Tebbutt Niall C, Mariadason John M
Abstract excerpt
Advanced biliary tract cancer (BTC) has a poor prognosis and limited treatment options. The PI3K/Akt/mTOR signalling pathway is hyperactivated in a subset of BTCs, and clinical activity of the mTOR inhibitor everolimus has been observed in some patients with BTC. The goal of this study was to identify biomarkers predictive of everolimus response. Twenty BTC cell lines were assessed for everolimus sensitivity with...
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