Article
Local medial microenvironment directs phenotypic modulation of smooth muscle cells after experimental renal transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jun 2012
Boersema M, Katta K, Rienstra H, Molema G, Nguyen T Q, Goldschmeding R, Navis G, van den Born J, Popa E R, Hillebrands J L
Abstract excerpt
Smooth muscle cells (SMCs) play a key role in the pathogenesis of occlusive vascular diseases, including transplant vasculopathy. Neointimal SMCs in experimental renal transplant vasculopathy are graft-derived. We propose that neointimal SMCs in renal allografts are derived from the vascular media resulting from a transplantation-induced phenotypic switch. We examined the molecular changes in the medial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.