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Article

Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib-mediated immunoregulation.

Journal of translational medicine - 12 Aug 2013

He Sisi, Yin Tao, Li Dan, Gao Xiang, Wan Yang, Ma Xuelei, Ye Tinghong, Guo Fuchun, Sun Jianhong, Lin Ziqiang, Wang Yongsheng

Abstract excerpt

BACKGROUND: Natural killer (NK) cells can kill tumor cells in a non-MHC-restricted manner. However, cancer cells frequently escape from the attack of NK cells by multiple ways. In this study, we investigated the effect of gefitinib on the interaction between NK cells and lung cancer cells. METHODS: ⁵¹Cr release assay, CD107a assay, and IFN-γ secretion assay were performed to detect the sensitivity of lung cancer...

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Source

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Identifiers

PMID: 23937717
DOI: 10.1186/1479-5876-11-186
PMCID: PMC3766712

Genes

EGFR
MICA
ULBP1
ULBP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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